|
Titre :
|
Studies on the risk assessment of Listeria monocytogenes
|
|
Auteurs :
|
S. Notermans ;
J. Difrenne ;
P. Teunis ;
T. Chackraborty
|
|
Type de document :
|
article/chapitre/communication
|
|
Année de publication :
|
1998
|
|
Format :
|
p. 244-248
|
|
Langues:
|
= Anglais
|
|
Catégories :
|
HYGIENE PATHOLOGIE
|
|
Mots-clés:
|
BACTERIE PATHOGENE
;
PRODUIT ALIMENTAIRE
;
EVALUATION DES RISQUES
;
SANTE
|
|
Résumé :
|
Humans are frequently exposed to Listeria monocytogenes, and high numbers may be ingested during consumption of certain types of food. However, epidemiological investigations show that listeriosis is a rare disease. Risk assessment studies using an animal mouse model indicate that almost all L. Monocytogenes serovars present in food have clear virulent properties. The intravenous dose causing infection in 50% (TV ID50) Of mice not previously exposed to L. Monocytogenes (nonprotected mice) was 1.8 log(10) units. For mice previously exposed to L. Monocytogenes (immunologically protected mice), the IV ID50 was 5.6 log(10) units. The ID50 Of orally exposed nonprotected mice amounted to 6.5 log(10) units, and no significant effects of type of food (water/milk) and storage time at 5 °C (milk) were observed. The oral ID50 Of immunologically protected mice was >9.0 log(10) units. Furthermore, there was approximately 1-2 log(10) difference between the ID50 and the lethal dose causing death in 50% (LD50) The results show that both the intestinal barrier and the specific immune defense mechanism are highly effective in preventing infection of mice orally exposed to L. Monocytogenes.
|
|
Source :
|
Journal of Food Protection, vol.61, n°2
|
