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Titre :
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Biology of the NMDA receptor
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Auteurs :
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A. VanDongen, Editeur scientifique
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Type de document :
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ouvrage
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Editeur :
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Frontiers in neuroscience, 2009
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Collection :
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Frontiers in Neuroscience, ISSN 1662-453X
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ISBN/ISSN/EAN :
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978-1-4200-4414-0
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Format :
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342 p.
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Langues:
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= Anglais
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Mots-clés:
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BIOLOGIE
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RÉCEPTEUR
;
MÉTHYLE ASPARTATE
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Résumé :
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This book covers many aspects of the biology of NMDARs: their role in controlling structure and function of synapses and neurons during early development; how overstimulation of NMDARs results in excitotoxicity and contributes to several progressive brain disorders, including Huntington’s disease; the newly discovered and intriguing interactions of NMDARs and dopamine receptors that mediate reward in the central nervous system; the role of NMDARs in alcohol dependence and the promise of NMDAR-based therapeutics for treating alcoholism; how functional expression is controlled at the level of gene transcription by several families of transcription factors; how NMDAR activation regulates local synaptic protein synthesis required for long-term changes in synaptic strength; the modulation of NMDAR function by signaling cascades cumulating in activation of protein kinases and phosphatases; the importance of cellular mechanisms underlying trafficking and targeting of NMDAR protein for many of its physiological functions; how NMDAR-mediated calcium signaling in dendritic spines controls synaptic efficacy and spine morphology; the roles NMDARs play in different temporal phases of memory formation in Drosophila; the extracellular modulation of NMDARs by polyamines, subunit-specific inhibitors, zinc ions, and pH, and the structural bases for their effects; a detailed description of NMDAR pharmacology, structure–activity relationships of agonists and antagonists, and roads to therapeutic drug design; the physiological roles played by NMDARs and their molecular structures; NMDAR activation mechanisms and the therapeutic potential of allosteric modulators; and the novel role of presynaptically localized NMDARs in controlling synaptic plasticity.
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En ligne :
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http://www.ncbi.nlm.nih.gov/books/NBK5283
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